Physical Therapy Assistant Practice Exam 2026 - Free PTA Practice Questions and Study Guide

Autolytic debridement refers specifically to the process in which the body utilizes its own natural mechanisms to break down and remove nonviable (dead or damaged) tissue from a wound. This occurs through the action of the body’s own enzymes and phagocytes, which work to digest the necrotic tissue, promote healing, and prepare the wound bed for the growth of new tissue.

This method is considered a type of conservative debridement that is effective in promoting a moist wound environment, which is conducive to healing. Autolytic debridement is often facilitated by the use of appropriate dressings that maintain moisture and support the natural healing processes within the wound.

The other methods of debridement involve more direct intervention. For example, the use of external enzymes, mechanical methods, or surgical approaches employs different techniques that do not rely solely on the body’s own healing processes but instead apply external forces or agents to remove tissue.